Open Access

Review

Article ID: 3002

Preparation of antimicrobial polyamide fibers based on surface treatment

by Lei Li, Donghong Zhu, Fanmin Kong, Ang Xiao, Ziling Zhang, Haoqi Wang, Weizhou Yao, Yutian Duan

Nano and Medical Materials, Vol.5, No.1, 2025;

Antibacterial nylon fiber, a crucial functional material, has demonstrated substantial potential for applications in medical, textile, food packaging, and other fields. While conventional nylon fibers possess excellent mechanical properties, their lack of inherent antimicrobial functionality has spurred research into surface treatment methods, including modification and post-finishing techniques. These approaches enable the integration of antibacterial agents such as silver ions, copper ions, and chitosan while preserving fiber integrity. Despite this progress, challenges persist in durability, biocompatibility, and economic feasibility, driving ongoing innovation. This review focuses on surface treatment methods, including chemical modification, dyeing, and post-finishing, covering antibacterial agents, and antimicrobial performance, providing insights into structure-property relationships and optimization strategies. The advancement of antibacterial nylon fibers not only meets critical healthcare demands but also aligns with global sustainability goals, offering innovative solutions with significant societal and economic impact.

Open Access

Article

Article ID: 2466

The planetary ball milling of different powders yields similar granulometry

by Clarissa Ciarlantini, Antonella Piozzi, Sergio Ammendola

Nano and Medical Materials, Vol.5, No.1, 2025;

The main objectives of nanotechnology include the establishment of processes for the development and control of the nanoparticles’ size and shape. Bottom-up or top-down methods can be used to achieve these objectives, but independently various parameters such as rotational speed, temperature, revolution time, and others must be controlled. However, both methods can be expensive, especially from an industrial point of view. To reduce production costs, we have investigated the feasibility of applying an identical top-down process to compounds with different chemical and physical properties. Starting from powders with very variable particle size, we arrive at powders with a particle size practically indistinguishable from the point of view of pharmaceutical technology. This procedure can be useful in industrial preparations.

Open Access

Article

Article ID: 2119

Development of Nigella sativa (black seed) extract-loaded chitosan nanoparticles for targeting Klebsiella pneumoniae-induced metastatic colon cancer

by Cletus Anes Ukwubile, Otalu Otalu Jr, Semen Ibrahim Gangpete

Nano and Medical Materials, Vol.5, No.1, 2025;

Metastatic colon cancer remains a significant global health challenge, with increasing evidence linking microbial infections, such as Klebsiella pneumoniae, to cancer progression. This study focuses on the development of Nigella sativa (black seed) extract-loaded chitosan nanoparticles (NS-CNPs) as a targeted therapeutic approach against K. pneumoniae-induced metastatic colon cancer. NS-CNPs were synthesized using ionic gelation, yielding nanoparticles with an average size of 140 ± 5 nm, a polydispersity index (PDI) of 0.23 ± 0.02, and an encapsulation efficiency of 85.7 ± 4.3%. Morphological analysis confirmed their spherical shape. The NS-CNPs exhibited superior antibacterial efficacy against K. pneumoniae (zone of inhibition 22.00 ± 2.5 mm) compared to the crude extract (zone of inhibition 12.3 ± 0.1 mm), highlighting improved bioavailability and targeted delivery. Cytotoxicity studies on colon cancer cell lines showed a significant reduction in cell viability (IC₅₀ = 0.16 ± 0.01 µg/mL), accompanied by modulation of key cancer biomarkers such as TNF-α with values of 12.50 ± 1.2 and 13.70 ± 1.5 pg/mL. The treatment elevated malondialdehyde (MDA) levels by 48%, increased caspase-3 and Bax expression by 2.5-fold and 1.8-fold, respectively, while reducing anti-apoptotic Bcl-2 expression by 40%. These effects indicate oxidative stress induction and apoptosis activation. Furthermore, NS-CNPs suppressed tumor-promoting pathways and enhanced pro-apoptotic mechanisms, demonstrating dual antibacterial and anticancer functionalities. These findings underscore the therapeutic potential of NS-CNPs as a novel nanoplatform for combating K. pneumoniae-associated metastatic colon cancer, paving the way for integrative strategies in cancer treatment that address both microbial and tumorigenic factors.

Open Access

Review

Article ID: 2044

Biomedical applications of nanomaterials: A short review

by Hüseyin Okan Durmuş

Nano and Medical Materials, Vol.4, No.1, 2024;

Nanomaterials have emerged as transformative tools in the biomedical field due to their distinct physical and chemical properties. This review delves into the synthesis, classifications, and applications of nanomaterials, emphasizing advancements in drug delivery, bioimaging, and diagnostics. Unique aspects include a focused discussion on sol-gel synthesis methods and recent trends in nanomaterial applications for personalized medicine. The review concludes with a future perspective on overcoming challenges such as toxicity and regulatory issues, paving the way for sustainable biomedical innovations.

Open Access

Article

Article ID: 1895

Preparation of cuttlefish ink-porphyrin nanoconjugates and its application in photodynamic-photothermal synergistic treatment of tumor cells

by Wei Wang, Yuting Zhang, Yan Li, Yuzi Huang, Shuzhang Xiao, Wenquan Huang, Peng Geng

Nano and Medical Materials, Vol.4, No.1, 2024;

Biologically derived nanomaterials have gained increasing attention in tumor diagnosis and treatment due to their inherent biocompatibility. In this study, a nanoconjugate of cuttlefish ink (M, extracted from cuttlefish ink sacs) and meso-tetra (4-carboxyphenyl) porphyrin (TCPP), termed M-TCPP, was synthesized. The nanoparticle size of M-TCPP was approximately 120 nm, and it could be activated by a 660 nm light to induce the generation of reactive oxygen species (ROS) via TCPP for photodynamic therapy (PDT) of tumor cells. Additionally, when triggered by an 808 nm light (near-infrared light), the cuttlefish ink component efficiently converted light into heat for photothermal therapy (PTT) of tumor cells. Compared to standalone PDT or PTT, the synergistic combination of PDT-PTT resulted in significantly enhanced tumor cell destruction. Moreover, in vitro experiments demonstrated that M-TCPP exhibited no noticeable toxic side effects. The research offers some inspiration for the development of natural multifunctional biomaterials and their use in tumor therapy.

Open Access

Article

Article ID: 2170

Formulation and development of topical nano-emulgel TDDS for delivering Vitex Negundo as a painkiller: Enhancing effectiveness with natural essential oil permeation promoters in an innovative drug delivery system for rheumatoid arthritis treatment—A NDDS

by Bhandare Saurabh Dilip, Malode Sarika Shivaji

Nano and Medical Materials, Vol.4, No.1, 2024;

Vitex negundo is a powerful herbal anti-inflammatory with effects similar to those of non-steroidal anti-inflammatory drugs (NSAIDs), which are commonly used to treat rheumatoid arthritis. Despite its benefits, Vitex negundo shares some drawbacks with NSAIDs, including gastrointestinal side effects such as vomiting and poor transdermal penetration, which limits its effectiveness in transdermal and gastrointestinal drug delivery. This study aimed to enhance the bioavailability of Vitex negundo by developing nano-emulgel with reduced particle size and to assess their effectiveness in treating rheumatoid arthritis. The researchers utilised a modified emulsification-diffusion method to create nanosized dispersions of Vitex negundo, incorporating hydroxypropyl methylcellulose (HPMC) as a gelling agent. Essential oils were also included to improve skin penetration by interacting with the stratum corneum (SC), thus enhancing the absorption of both lipophilic and hydrophilic drugs. The prepared Vitex negundo nano-emulgel were evaluated for various parameters, including rheology, particle size, drug content, drug release percentage, and in-vitro diffusion. The results indicated favourable properties: the particle size was 120.10 nm, the zeta potential was ± 30 mV, drug content was 99.50%, drug release percentage was 98.92%, and drug diffusion was approximately 98%. The formulation also had a pH of 6.8 ± 0.1. Overall, the Vitex negundo nano-emulgel, formulated with HPMC and eucalyptus oil as a permeation enhancer, demonstrated potential as an effective topical treatment for oedema and rheumatoid arthritis. “The study illustrates the formulation process of a drug blended with a polymer matrix. The drug is uniformly dispersed within the polymer matrix through high-shear mixing, ensuring optimal integration and consistency in the final product. The process involves high-shear blending to achieve a homogenous mixture, enhancing the drug’s stability and release characteristics within the polymer matrix.”