Preparation of cuttlefish ink-porphyrin nanoconjugates and its application in photodynamic-photothermal synergistic treatment of tumor cells

  • Wei Wang College of Materials and Chemical Engineering, China Three Gorges University, Yichang 443002, China
  • Yuting Zhang College of Materials and Chemical Engineering, China Three Gorges University, Yichang 443002, China
  • Yan Li College of Materials and Chemical Engineering, China Three Gorges University, Yichang 443002, China
  • Yuzi Huang College of Materials and Chemical Engineering, China Three Gorges University, Yichang 443002, China
  • Shuzhang Xiao College of Materials and Chemical Engineering, China Three Gorges University, Yichang 443002, China
  • Wenquan Huang College of Medicine and Health Science, China Three Gorges University, Yichang 443002, China
  • Peng Geng College of Materials and Chemical Engineering, China Three Gorges University, Yichang 443002, China; Hubei Three Gorges Laboratory, Yichang 443007, China
Article ID: 1895
49 Views, 18 PDF Downloads, 3 Supp.file Downloads
DOI: https://doi.org/10.59400/nmm.v4i1.1895
Keywords: biomaterials; cuttlefish ink; photodynamic therapy; photothermal therapy; tumor cell

Abstract

Biologically derived nanomaterials have gained increasing attention in tumor diagnosis and treatment due to their inherent biocompatibility. In this study, a nanoconjugate of cuttlefish ink (M, extracted from cuttlefish ink sacs) and meso-tetra (4-carboxyphenyl) porphyrin (TCPP), termed M-TCPP, was synthesized. The nanoparticle size of M-TCPP was approximately 120 nm, and it could be activated by a 660 nm light to induce the generation of reactive oxygen species (ROS) via TCPP for photodynamic therapy (PDT) of tumor cells. Additionally, when triggered by an 808 nm light (near-infrared light), the cuttlefish ink component efficiently converted light into heat for photothermal therapy (PTT) of tumor cells. Compared to standalone PDT or PTT, the synergistic combination of PDT-PTT resulted in significantly enhanced tumor cell destruction. Moreover, in vitro experiments demonstrated that M-TCPP exhibited no noticeable toxic side effects. The research offers some inspiration for the development of natural multifunctional biomaterials and their use in tumor therapy.

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Published
2024-12-05
How to Cite
Wang, W., Zhang, Y., Li, Y., Huang, Y., Xiao, S., Huang, W., & Geng, P. (2024). Preparation of cuttlefish ink-porphyrin nanoconjugates and its application in photodynamic-photothermal synergistic treatment of tumor cells. Nano and Medical Materials, 4(1), 1895. https://doi.org/10.59400/nmm.v4i1.1895
Issue
Vol. 4 No. 1 (2024)
Section
Article

Copyright (c) 2024 Wei Wang, Yuting Zhang, Yan Li, Yuzi Huang, Shuzhang Xiao, Wenquan Huang, Peng Geng

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