Tetrahedral DNA nanocages as delivery agent for biological and biomedical applications

Landon Dahle; Payal Vaswani; Dhiraj Bhatia

doi:10.59400/nmm.v3i1.151

Landon Dahle Biomedical Engineering Department, Texas A&M University
Payal Vaswani Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar
Dhiraj Bhatia Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar

Article ID: 151

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DOI: https://doi.org/10.59400/nmm.v3i1.151

Keywords: tetrahedral DNA nanocages, delivery agents, biological applications, drug delivery, imaging, targeted therapies

Abstract

Tetrahedral DNA nanocages have emerged as highly versatile tools for delivering a wide range of biological agents by leveraging their unique structural properties and functional adaptability. This review critically examines the field of tetrahedral DNA nanocages as delivery agents, communicating key findings and insights from existing literature. An extensive examination of the advantages of tetrahedral DNA nanocages as drug-delivery vehicles is outlined, with specific emphasis on their exceptional cargo encapsulation efficiency and controlled release capabilities. An in-depth exploration of in vivo studies and preclinical models is provided, encompassing comprehensive assessments of therapeutic efficacy, pharmacokinetics, toxicity, safety, and targeting capabilities. Moreover, the potential of tetrahedral DNA nanocages in regenerative medicine applications is highlighted. To address future challenges and directions in the field, the review emphasizes the importance of optimization of large-scale synthesis and translational studies. The significant role of tetrahedral DNA nanocages as delivery agents is underscored, showcasing their potential to revolutionize the landscape of targeted and programmable therapeutic interventions.

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