Description

Journal of Toxicological Studies (JTS, eISSN: 3029-2832) serves as a vital academic platform for researchers, practitioners in the field of toxicology. By publishing high-quality articles that include original research, comprehensive reviews, and perspectives, JTS strives to disseminate knowledge related to the assessment and management of medicial toxicology or chemical hazards. The journal is committed to fostering scientific discourse and innovation in toxicological research, making it an essential reference for those dedicated to understanding and mitigating the impacts of toxins in various environments.

Latest Articles

  • Open Access

    Article

    Article ID: 1924

    Impact of salinity on density and mechanical strength of Avicennia germinans wood exposed to marine oil pollution in the Gabon Estuary

    by Mabicka Iwangou Saint Bickolard, Safou Tchiama Rodrigue, Besserer Arnaud, Andzi Barhé Timoléon, Gérardin Philippe

    Journal of Toxicological Studies, Vol.3, No.1, 2025;

    Located at the interface between land and sea, mangroves develop both near the sea and inland. However, mangroves that develop inland have to cope with variable, high salinity; and urban pollution, as is the case with the mangroves of the Ambowé lagoon in Greater Libreville. Salinity is an important parameter for mangrove growth. The aim of this work was; yes itto show the impact of salinity on the density and mechanical strength of A. germinans wood exposed to hydrocarbon pollution. To this end, wood samples taken from the polluted Ambowé site were analyzed in the laboratory for wood and physical-mechanical properties. The data obtained were compared with wood samples taken from the unpolluted Oveng site, which has a higher salinity. The results show that for the polluted wood showed wider rings, lower wood density and mechanical strength with values of 0.91 ± 0.05 and 70.28 MPa, respectively. Also, the rings and vessels of Oveng wood are narrower than those of Ambowé wood. These differences are linked to salinity. Salinity therefore affects the density and mechanical strength of A. germinans wood exposed to hydrocarbon pollution.

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  • Open Access

    Article

    Article ID: 1798

    The evolution of the EFSA OpenFoodTox database

    by Nadia Iovine, Alessandra Roncaglioni, Luca Sartori, Chihae Yang, Emilio Benfenati

    Journal of Toxicological Studies, Vol.3, No.1, 2025;

    Since its establishment in 2002, the European Food Safety Authority (EFSA) has been providing independent scientific advice on risks associated with the food chain. This manuscript provides a description of EFSA’s chemical hazards database OpenFoodTox (OFT), future perspectives and activities. OFT aims at mapping all the hazard identification and characterisation data that have been published in outputs from EFSA throughout the years. To date, OFT contains data for more than 5700 chemical substances in the food/feed chain. In line with the One Substance-One Assessment approach as part of the Chemicals Strategy for Sustainability, EFSA aims to further improve data quality and interoperability of OFT with IUCLID 6 and the EU Common Data Platform on Chemical Safety. To enhance its usability as a supporting tool for risk assessment activities, OFT will be migrated to IUCLID 6. More data will be collected and added to OFT, including endpoints related to in vitro assays, non-critical effects and exposure values. Furthermore, new in silico models (e.g., tools for read-across and grouping) will be developed based on the data already present in OFT for chemicals and endpoints that have been tested, with the aim of estimating the corresponding properties for the untested chemicals and endpoints.

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  • Open Access

    Perspective

    Article ID: 1970

    Risk assessments of contaminants of environmental concern need to address future scenarios to effectively protect human health and ecosystems

    by Denis Moledo de Souza Abessa

    Journal of Toxicological Studies, Vol.3, No.1, 2025;

    This article intends to discuss some limitations of the current approaches used to assess human health and environmental risks caused by contaminants of emerging concern (CECs). Human health and environmental risk assessments of CECs are normally based on a relationship between measured and predicted environmental concentrations (MECs and PECs, respectively) often estimated based on past conditions, and the respective predicted no-effect concentrations (PNECs). However, for most of chemicals, emissions continue to increase following the population growth and increasing polluting activities, resulting in a continuous rise of contaminants concentrations in the environmental compartments and the consequent increase of risks associated with them. Therefore, risk predictions based on past data may be unreliable and ineffective to support actions aimed to protect the environment, particularly in developing countries where pollutants monitoring are lacking or regulations are based on few academic studies. In this context, new tools need to be incorporated to improve the risk assessment protocols. Projections of future scenarios may predict the environmental concentrations of chemicals, allowing decision makers to establish appropriate actions to control the emissions and avoid the emergence of risks to human health and ecosystems before critical conditions are achieved. Thus, effective policies to control pollution and its effects would be taken.

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  • Open Access

    Article

    Article ID: 1660

    Physico-chemical characterization of a low cost biosorbent for efficient sequestration of heavy metals

    by Vimala Kumari Nagendra Prasad Meena Devi

    Journal of Toxicological Studies, Vol.3, No.1, 2025;

    Heavy metal pollution from industrial effluents poses significant environmental and public health challenges, particularly in aquatic ecosystems. Traditional wastewater treatment methods, are effective but often expensive, labor-intensive, and generate hazardous waste. Biosorption, using biological materials, presents a cost-effective and environment friendly alternative for heavy metal removal. The present study investigates the potential of Madhuca indica oil cake, a by-product of oil extraction can be used as a biosorbent for heavy metal sequestration. The oil cake was characterized by its physicochemical properties, including specific gravity (1.298 g/cm3), bulk density (0.66184 kg/m3), moisture content (11.34%), and dry matter content (88.66%). These properties suggest the oil cake is dense, nutrient-rich, and easy to handle and store. Fourier Transform Infrared (FTIR) spectroscopy was used to analyze the functional groups in the oil cake before and after drying at 105 °C. The results showed minimal changes in the chemical composition, with a slight shift in peak intensities indicating concentration effects due to drying. This stability is crucial for applications requiring intact bioactive compounds. The study highlights the versatility of Madhuca indica oil cake for multiple uses, including animal feed, fertilizer, and biomass for bioenergy. Furthermore, its potential as a biosorbent for heavy metal removal underscores its promise for environmental remediation. The study concludes that further research could optimize the utilization of Madhuca indica oil cake in agriculture and pollution control, contributing to sustainable environmental management.

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  • Open Access

    Review

    Article ID: 1990

    Facts of the main rigorous heavy metals affecting Waterfowls health, genetics, and migration habits

    by Humaira Aslam, Manel Mansour, Shehla Honey, Muhammad Ahsan Ashraf, Aman Ullah, Ali Umar, Nazia Nusrat, Misbah Ullah Khan, Jehanzaib Sohail, Muhammad Mudassar Hashim, Muhammad waseem Aslam, Mustansar Abbas

    Journal of Toxicological Studies, Vol.3, No.1, 2025;

    Swans, geese, and ducklings falling under the Anatedae group are important waterfowls to water systems. In this study, migratory birds that cover long distances are affected by some environmental stressors, especially heavy metal contamination. Al, Pb, Hg, Cd, Ni, and other similar metals are received by water structures and are natural in water, but these metals in high concentrations negatively affect the quality of water. Birds drink the polluted water and feed on polluted food, which results in the bioaccumulation of these metals in their body tissues. It leads to several diseases in body organs such as the liver, kidneys, and brain, respiratory disorders, oxidative stress, and alterations in metabolism activities. Some heavy metals known include lead and mercury, which poison the enzymes, which are crucial in the energy metabolism, hence survival. Effects of long-term exposure are DNA change, hereditary disorders, and reproductive problems such as eggshell hardness and fertility. Birds and waterfowl in particular, which may act as bioassays of the ecosystem, have experienced falls in their population because of contamination from heavy metals, which affects food chains through migration. This can only be done through concerted efforts among nations, constant monitoring of the quality of water in these habitats, and controlling water pollution with a view to preserving these birds and their habitats.

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  • Open Access

    Article

    Article ID: 1794

    Effects of flubendiamide and lead exposure on circulating thyroid hormone levels in buffalo (Bubalus bubalis) calves

    by Amita Ranjan, Vinod Kumar Dumka, Rahini Parsoya, Rakesh Ranjan

    Journal of Toxicological Studies, Vol.3, No.1, 2025;

    The current investigation aimed to find how exposure to lead and flubendiamide affected the amounts of thyroid hormone levels in buffalo calves’ blood. For ninety days, male buffalo calves were given lead acetate orally at a rate of 9.2 mg/kg bw/day and flubendiamide orally at a rate of 0.024 mg/kg bw/day, either in combination or separately. T3 and T4 levels in blood decreased in response to both flubendiamide and lead exposure alone. When lead and flubendiamide were administered together, the animals’ T3 and T4 levels declined less than when lead and flubendiamide were administered separately. TSH activity increased markedly in rats exposed to both lead and flubendiamide, but not consistently in animals treated with flubendiamide alone. Results of the present study indicated thyrotoxic potential of flubendiamide and lead in buffalo calves. However, further study is required to elucidate the mechanism of thyrotoxic potential of flubendiamide and to understand the interactive effects of these two toxicants on thyroid function in mammals.

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Announcements

Studies on microplastics featured in Nature and Journal of Toxicological Studies highlight their adverse impacts on health

2024-10-14

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Plastics have become ubiquitous in every facet of human daily life, and those with a particle size of less than 5mm are termed microplastics. These microplastics are readily ingested by living organisms and eventually make their way into the human body through the food chain. Not only are these minuscule plastic particles pervasive in soil, seas, and air, but they also represent an environmental issue that is increasingly demonstrating its severity. Moreover, they have infiltrated human bodies, posing a significant threat to human health.

Read more about Studies on microplastics featured in Nature and Journal of Toxicological Studies highlight their adverse impacts on health