Description

Journal of Toxicological Studies (JTS) is an open access peer-reviewed journal, and it focuses on topics related to toxiology. Articles including case studies, reviews, research articles are welcomed.

The subjects include but are not limited to:

  • Toxicity assessment of emerging pollutants
  • Metals and radioactive materials
  • Human toxicology and epidemiology
  • Agrochemicals and food toxicology
  • Exposure analysis and risk assessment
  • Evaluation of cosmetic safety and toxicity
  • Immunological toxicology
  • New methods for toxicological research
  • Ecotoxicology
  • Genotoxicity

Latest Articles

  • Open Access

    Article

    Article ID: 1359

    An in-depth investigation correlating lifestyle choices with cognitive well-being: Public health implications of food packaging trends and memory capacity, an intensive research study

    by Saurabh Dilip Bhandare

    Journal of Toxicological Studies, Vol.2, No.2, 2024; 114 Views, 82 PDF Downloads

    This study presents a multifaceted investigation into the interplay between lifestyle choices, cognitive well-being, and potential health risks associated with food packaging materials. Statistical analyses of memory patterns among diverse population groups, including healthy volunteers, addicted individuals, and those consuming roadside food form street vendors or hawkers, reveal intriguing correlations. The study also conducts a rigorous chemical analysis of newspaper packaging, uncovering significant concerns related to lead contamination. The findings emphasise the need for heightened awareness, further research, and interventions to address potential health risks and ensure the safety of packaging materials. Overall, this research contributes valuable, insightful information that has implications for public health initiatives and packaging industry practices. This is a qualitative study correlating lifestyle choices with cognitive well-being and specific food packaging that impacts the memory and health too. Key findings reveal intriguing correlations between lifestyle habits, the type of food packaging used, and memory capacity. The study’s chemical analysis of newspaper packaging uncovered significant lead contamination, raising serious public health concerns. These findings emphasise the necessity for heightened awareness, and targeted interventions to mitigate health risks.

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  • Open Access

    Article

    Article ID: 1372

    Investigation of adverse effects following COVID-19 immunization: A comparison of six vaccines in Pakistan

    by Ayesha Sana, Saba Noor, Kashif Iqbal, Shazma Maryam, Najam-us- Sahar, Muhammad Sufyan

    Journal of Toxicological Studies, Vol.2, No.2, 2024; 73 Views, 57 PDF Downloads

    Aim: This survey was created to find out the prevalence of immunized people and its objectives include evaluating how the general public responded to the six different COVID-19 vaccination and the range and severity of six COVID-19 vaccine adverse effects that participants self-reported. Methodology: A cross-sectional survey using questionnaires was carried out. The development and proper validation of a self-administered questionnaire were completed. SPSS version 23.0 was used to analyze data. For statistical evaluation, descriptive analysis was used to determine demographic frequency and percentage, other questions, and adverse effects. Analysis of associations between study variables was done using chi-square tests. Each participant gave verbal consent before the collection of data. The participants’ confidentiality was protected. Results: A total of 493 participants were enrolled in the study, with 42.6% of them falling between the age range of 21 to 30 years. A total of 493 people had acquired vaccinations; of these, 25.96% had obtained Sinopharm, 22.31% had received Cansino Pakvac, 16.63% had acquired Pfizer, 12.57% had given Sinovac, 11.96% had obtained Moderna, and 10.54% had received AstraZeneca. These vaccines’ most significant adverse effects included injection site pain, fever, headache, weariness, myalgia, joint pain, and chills. Conclusion: Even though after receiving the first dose of the vaccination, over 55% of those who received it reported musculoskeletal side effects, such as muscle aches and fatigue, we found that participants generally accepted the vaccination. After obtaining the second vaccine shot, it was observed that participants did not have as many adverse effects.

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  • Open Access

    Article

    Article ID: 1393

    Evaluation of the crude chitinases toxicity on the reproductive system of Callosobruchus maculatus (Coleoptera: Bruchidae)

    by Laribi-Habchi Hassiba, Amrouche Zoheir, Boudjamaa Nouara, Mohamed Mahmoud Fadhila, Medjdoub Ouafaa, Akroum-Amrouche Dahbia, Akroum Hamza

    Journal of Toxicological Studies, Vol.2, No.2, 2024; 101 Views, 54 PDF Downloads

    Insecticides represent the most used control method against the insect pests of stored food products. But there are strains of insects which are resistant to these insecticides: it is the case of the beetle of the chickpea Callosobruchus maculatus . The present study has for objective the evaluation of the biological activity of chitinolytic enzymes extracted from the fish offals Scorpaena scrofa (scorpion fish) on this beetle at different doses (3%, 6%, 9%, 12%, 15% and 21%) prepared with the buffer solution. The results obtained from three treatments (T 1 , T 2 and T 3 ) realized according to the dose of the crude enzyme and the time of exposure were compared with those of the controls and have showed a very significant efficiency of our crude enzyme on the reduction of the fertility rate of 100% by treating the couple (T 1 ) at the same time as to treat the male (T 3 ) and the female (T 2 ) separately with the strongest dose (21%) for 48 h of exposure. It would be thus desirable to demonstrate the activity of these enzymes in the real conditions of storage.

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  • Open Access

    Article

    Article ID: 1238

    A study on membrane enzyme Na+-K+-ATPase in lindane exposed fish, Channa punctatus

    by Aradhna Gupta, Bechan Sharma

    Journal of Toxicological Studies, Vol.2, No.2, 2024; 54 Views, 42 PDF Downloads

    Na + -K + -ATPase is a membrane bound enzyme responsible for the transport of ions through the membrane and immediate release of energy. This enzyme is known to be an early target for oxygen radical induced damage to intact cell. Exposure of C. punctatus to subacute concentrations of lindane for 96 h caused significant reduction in the activities of Na + -K + -ATPase in all the tissues of the fish tested; brain being maximally affected and the heart being least affected organ at the highest concentration of lindane (0.1 mg/L). The effect of pesticide was concentration dependent. The percent decrease in the activity of Na + -K + -ATPase in brain, gills, heart, kidney, liver and muscle was found to be 36.7, 23.4, 19.2, 29, 22.9 and 29.7, respectively. The order of level of enzyme activity recorded was as following: liver > gills > kidney > brain > muscle > heart in the control.

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  • Open Access

    Article

    Article ID: 1423

    Microstructure of the dentate gyrus and spontaneous alternation behaviour of male Wistar rats following Rauvolfia vomitoria and Gongronema latifolium extracts administration

    by Moses B. Ekong, Ini-Obong G. Essien, Cecilia K. Bassey, Ogechi M. Akanu

    Journal of Toxicological Studies, Vol.2, No.2, 2024; 61 Views, 60 PDF Downloads

    Rauvolfia vomitoria (RV) and Gongronema latifolium (GL) are medicinal plants used for the local treatment of various health issues. Their activities on the brain motivated this investigation on the histology and immunohistochemistry of the dentate gyrus and spontaneous alternation behaviour (SAB) of adult Wistar rats following RV root bark and GL leaf extract administrations. Twenty young adult Wistar rats (130–160 g) were assigned into four groups: Group 1 served as the control (5 mL/kg of distilled water placebo), while the test groups 2–4 were, respectively, singly administered 200 of mg/kg of RV, 200 of mg/kg of GL, and their combination. The administrations were oral and lasted for seven days. A T-maze SAB test was carried out, and the animals were sacrificed immediately after ketamine hydrochloride intraperitoneal anaesthesia. Serial sections of the hippocampal region from perfused rat brains were stained with Cresyl fast violet and immunolabelled with neuronal nuclei (NeuN) for neurons and glial fibrillary acidic protein (GFAP) for astrocytes. Results indicated that SAB was significantly ( p < 0.05) lower in the test groups. Histologically, Nissl was less distributed in the RV and GL-only groups but not in the combined group, while there was less NeuN positivity in the RV group, with the GL and RV + GL groups not affected. There was less positive GFAP expression in individual RV and GL groups, but not in the RV + GL combined group, all compared with the control. In conclusion, the combination of RV and GL did not improve SAB but modulated Nissl, NeuN, and GFAP expression in the dentate gyrus.

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