A study on membrane enzyme Na+-K+-ATPase in lindane exposed fish, Channa punctatus

Aradhna Gupta; Bechan  Sharma

doi:10.59400/jts.v2i2.1238

Aradhna Gupta Department of Biochemistry, University of Allahabad, Allahabad 211002, India
Bechan Sharma Department of Biochemistry, University of Allahabad, Allahabad 211002, India

Ariticle ID: 1238

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DOI: https://doi.org/10.59400/jts.v2i2.1238

Keywords: lindane; Na-K-ATPase; organs

Abstract

Na⁺-K⁺-ATPase is a membrane-bound enzyme responsible for the transport of ions through the membrane and the immediate release of energy. This enzyme is known to be an early target for oxygen radical-induced damage to intact cells. Exposure of C. punctatus to subacute concentrations of lindane for 96 h caused a significant reduction in the activities of Na⁺-K⁺-ATPase in all the tissues of the fish tested, with the brain being maximally affected and the heart being the least affected organ at the highest concentration of lindane (0.1 mg/L). The effect of pesticides was concentration-dependent. The percent decrease in the activity of Na⁺-K⁺-ATPase in brain, gills, heart, kidney, liver, and muscle was found to be 36.7, 23.4, 19.2, 29, 22.9, and 29.7, respectively. The order of level of enzyme activity recorded was as follows: liver > gills > kidney > brain > muscle > heart in the control.

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