Biofabricated MoO3 nanoparticles for biomedical applications: Antibacterial efficacy, hemocompatibility, and wound healing properties

Anisha Salim; Subramaniam Sadhasivam

doi:10.59400/nmm.v3i1.73

Anisha Salim Department of Microbial Biotechnology, Bharathiar University
Subramaniam Sadhasivam Department of Microbial Biotechnology, Bharathiar University; Centre for International Affairs, Bharathiar University

Ariticle ID: 73

199 Views, 109 PDF Downloads

DOI: https://doi.org/10.59400/nmm.v3i1.73

Keywords: green synthesis, MoO3 NPs, hemocompatability, cytotoxicity, antimicrobial, wound healing activity

Abstract

This study presents a simple, eco-friendly, and cost-effective method for synthesizing molybdenum trioxide nanoparticles (MoO₃ NPs) using the medicinal plant Hemigraphis alternata. The physicochemical characterization confirmed the formation of orthorhombic MoO₃ NPs. The green synthesized NPs exhibited remarkable antioxidant and antimicrobial properties against multi drug-resistant bacteria (S. aureus and P. aeruginosa) and fungi (A. niger and C. albicans) in a concentration-dependent manner. Hemocompatibility assessments on human erythrocytes suggested their potential application in wound healing. Cytotoxicity evaluations on mouse fibroblast cell lines demonstrated no harmful effects. Furthermore, in vitro scratch assays revealed over 90% wound healing activity without cytotoxicity. The findings indicate that these green synthesized MoO₃ NPs hold promise for incorporation into wound dressings, offering a safe and effective solution for infectious wound healing. This study represents a novel effort to update practitioners on the latest developments in the widespread use of green synthesized NPs in medicine.

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