Nano drug delivery-benefits, limitations and future perspective
Abstract
In many aspects, nanotechnology aids in the enhancement of the pharmacological and therapeutic qualities of traditional medications. Because nanocarriers can pass through the blood-brain barrier, they can be studied at the cellular level. Although nanodrug delivery has several drawbacks, it can adapt to minute alterations in the surrounding cellular environment, which helps to solve a lot of the present drug delivery issues. Strict standards should be developed by regulators to address their shortcomings. It is generally expected that during the coming years, nanotechnology will continue to advance and spread throughout many facets of science and life. The medical sciences will benefit from the applications of nanotechnology, which will include drug delivery systems, patient therapies, and diagnostic tools. Nanotechnology has been investigated thus far for targeted delivery and diagnosis. It is important to remember that the field of nanotechnology will only grow in the future in the healthcare industry. We provide some important insights about nanodrug delivery from this angle.
References
Seema V, Ravi V, Swamy DN, Mohan K. Biomedical applications of nanomaterials-updated until 2022: A mini review. Academic Journal of Polymer Science 2022; 5(4): 555670. doi: 10.19080/AJOP.2022.05.555670
Bonifácio BV, da Silva PB, dos Santos Ramos MA, et al. Nanotechnology-based drug delivery systems and herbal medicines: A review. International Journal of Nanomedicine 2014; 9: 1–15. doi: 10.2147/IJN.S52634
Afzal O, Altamimi ASA, Nadeem MS, et al. Nanoparticles in drug delivery: From history to therapeutic applications. Nanomaterials 2022; 12(24): 4494. doi: 10.3390/nano12244494
Astruc D. Introduction to nanomedicine. Molecules 2016; 21(1): 4. doi: 10.3390/molecules21010004
Giunta CI, Cea-Rama I, Alonso S, et al. Tuning the properties of natural promiscuous enzymes by engineering their nano environment. ACS Nano 2020; 14(12): 17652–17664. doi: 10.1021/acsnano.0c08716
Deng Y, Zhang X, Shen H, et al. Application of the nano-drug delivery system in treatment of cardiovascular diseases. Frontiers in Bioengineering and Biotechnology 2020; 7: 489. doi: 10.3389/fbioe.2019.00489
Mirza AZ, Siddiqui FA. Nanomedicine and drug delivery: A mini review. International Nano Letters 2014; 4(1): 94. doi: 10.1007/s40089-014-0094-7
Patra JK, Das G, Fraceto LF, et al. Nano based drug delivery systems: Recent developments and future prospects. Journal of Nanobiotechnology 2018; 16(1): 71. doi: 10.1186/s12951-018-0392-8
Peer D, Karp JM, Hong S, et al. Nanocarriers as an emerging platform for cancer therapy. In: Balogh LP (editor). Nano-Enabled Medical Applications. Jenny Stanford Publishing; 2021. pp. 61–91.
Mitchell MJ, Billingsley MM, Haley RM, et al. Engineering precision nanoparticles for drug delivery. Nature Reviews Drug Discovery 2021; 20: 101–124. doi: 10.1038/s41573-020-0090-8
Zhang J, Zhan P, Tian H. Recent updates in the polysaccharides-based nano-biocarriers for drugs delivery and its application in diseases treatment: A review. International Journal of Biological Macromolecules 2021; 182: 115–128. doi: 10.1016/j.ijbiomac.2021.04.009
Adepu S, Ramakrishna S. Controlled drug delivery systems: Current status and future directions. Molecules 2021; 26(19): 5905. doi: 10.3390/molecules26195905
Jain KK. An overview of delivery systems. In: Clifton NJ (editor). Methods in Molecular Biology. Humana Press; 2020. Volume 2059. pp. 1–54. doi: 10.1007/978-1-4939-9798-5_1
Berillo D, Yeskendir A, Zharkinbekov Z, et al. Peptide-based drug delivery systems. Medicina 2021; 57(11): 1209. doi: 10.3390/medicina57111209
Ashique S, Sandhu NK, Chawla V, Chawla PA. Targeted drug delivery: Trends and perspectives. Current Drug Delivery 2021; 18(10): 1435–1455. doi: 10.2174/1567201818666210609161301
Sabbagh F, Kim BS. Recent advances in polymeric transdermal drug delivery systems. Journal of Controlled Release 2022; 341: 132–146. doi: 10.1016/j.jconrel.2021.11.025
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