Recent advances and future challenges of nano-based drug delivery systems
Abstract
Nanomedicine and nano-delivery systems constitute an emerging and swiftly progressing discipline, employing nanoscale materials for diagnostic tools and targeted, controlled administration of therapeutic agents. Nanotechnology offers substantial advantages for treating chronic ailments, facilitating precise, site-specific delivery of therapeutic agents. Recent applications encompass a diverse array of nanomedicine implementations, including chemotherapeutic, biological, and immunotherapeutic agents, for treating diverse medical conditions. This comprehensive review provides an updated summary of recent strides in the realm of nanomedicines and nano-based drug delivery systems. It critically examines the utilization of nanomaterials to enhance the effectiveness of both novel and established drugs (e.g., natural products) and to enable selective disease diagnosis through the identification of disease marker molecules. The review also addresses the prospects and challenges associated with the transition of nanomedicines from synthetic or natural origins to their practical clinical deployment. Furthermore, the document offers insights into prevailing trends and future prospects within the domain of nanomedicine.
References
Nasrollahzadeh M, Saiadi SM, Sajjadi M, Issaabadi Z. An introduction to nanotechnology. In: Interface Science and Technology. Elsevier; 2019.
Doran J, Ryan G. Does nanotechnology research generate an innovation premium over other types of research? Evidence from Ireland. Technology in Society 2019; 59: 101183. doi: 10.1016/j.techsoc.2019.101183
Qiao L, Yang H, Gao S, et al. Research progress on self-assembled nanodrug delivery systems. Journal of Materials Chemistry B 2022; 10(12): 1908–1922. doi: 10.1039/D1TB02470A
Osman N, Devnarain N, Omolo CA, et al. Surface modification of nano-drug delivery systems for enhancing antibiotic delivery and activity. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2022; 14(1): e1758. doi: 10.1002/wnan.1758
Jain KK. An overview of drug delivery systems. In: Jain KK (editor). Drug Delivery Systems. Humana; 2019. Volume 2059, pp. 1–54.
Wang Y, Sun T, Jiang C. Nanodrug delivery systems for ferroptosis-based cancer therapy. Journal of Controlled Release 2022; 344: 289–301. doi: 10.1016/j.jconrel.2022.01.034
Wang C, Li F, Zhang T, et al. Recent advances in anti-multidrug resistance for nano-drug delivery system. Drug Delivery 2022; 29(1): 1684–1697. doi: 10.1080/10717544.2022.2079771
Li R, Chen Z, Li J, et al. Nano-drug delivery systems for T cell-based immunotherapy. Nano Today 2022; 46: 101621. doi: 10.1016/j.nantod.2022.101621
Ma Z, Li B, Peng J, Guo D. Recent development of drug delivery systems through microfluidics: From synthesis to evaluation. Pharmaceutics 2022; 14(2): 434. doi: 10.3390/pharmaceutics14020434
Tian C, Zheng S, Liu X, Kamei K. Tumor-on-a-chip model for advancement of anti-cancer nano drug delivery system. Journal of Nanobiotechnology 2022; 20(1): 1–16. doi: 10.1186/s12951-022-01552-0
Liu W, Ma Z, Wang Y, Yang J. Multiple nano-drug delivery systems for intervertebral disc degeneration: Current status and future perspectives. Bioactive Materials 2022; 23: 274–299. doi: 10.1016/j.bioactmat.2022.11.006
Qin J, Wang X, Fan G, et al. Recent advances in nanodrug delivery system for tumor combination treatment based on photothermal therapy. Advanced Therapeutics 2023; 6(3): 2200218. doi: 10.1002/adtp.202200218
Chavda VP, Patel AB, Mistry KJ, et al. Nano-drug delivery systems entrapping natural bioactive compounds for cancer: Recent progress and future challenges. Frontiers in Oncology 2022; 12: 867655. doi: 10.3389/fonc.2022.867655
Jain A, Jain SK. In vitro release kinetics model fitting of liposomes: An insight. Chemistry and Physics of Lipids 2016; 201: 28–40. doi: 10.1016/j.chemphyslip.2016.10.005
Babu A, Templeton AK, Munshi A, et al. Nanodrug delivery systems: A promising technology for detection, diagnosis, and treatment of cancer. AAPS PharmSciTech 2014; 15(3): 709–721. doi: 10.1208/s12249-014-0089-8
Wang J, Guo J, Wei Z. Strategies for liposome drug delivery systems to improve tumor treatment efficacy. AAPS PharmSciTech 2021; 23(1): 27. doi: 10.1208/s12249-021-02179-4
Dimov N, Kastner E, Hussain M, et al. Formation and purification of tailored liposomes for drug delivery using a module-based micro continuous-flow system. Scientific Reports 2017; 7(1): 12045. doi: 10.1038/s41598-017-11533-1
Bozzuto G, Molinari A. Liposomes as nanomedical devices. International Journal of Nanomedicine 2015; 10: 975–999. doi: 10.2147/IJN.S68861
Sercombe L, Veerati T, Moheimani F, et al. Advances and challenges of liposome assisted drug delivery. Frontiers in Pharmacology 2015; 6: 286. doi: 10.3389/fphar.2015.00286
Kotla NG, Chandrasekar B, Rooney P, et al. Biomimetic lipid-based nanosystems for enhanced dermal delivery of drugs and bioactive agents. ACS Biomaterials Science & Engineering 2017; 3(7): 1262–1272. doi: 10.1021/acsbiomaterials.6b00681
Nakhaei P, Margiana R, Bokov DO, et al. Liposomes: Structure, biomedical applications, and stability parameters with emphasis on cholesterol. Frontiers in Bioengineering and Biotechnology 2021; 9: 705886. doi: 10.3389/fbioe.2021.705886
Sakurai Y, Kajimoto K, Hatakeyama H, Harashima H. Advances in an active and passive targeting to tumor and adipose tissues. Expert Opinion on Drug Delivery 2015; 12(1): 41–52. doi: 10.1517/17425247.2015.955847
Liu Y, Bravo KMC, Liu J. Targeted liposomal drug delivery: A nanoscience and biophysical perspective. Nanoscale Horizons 2021; 6(2): 78–94. doi: 10.1039/D0NH00605J
Attia MF, Anton A, Wallyn J, et al. An overview of active and passive targeting strategies to improve the nanocarriers efficiency to tumour sites. Journal of Pharmacy and Pharmacology 2019; 71(8): 1185–1198. doi: 10.1111/jphp.13098
Nunes SS, Fernandes RS, Cavalcante CH, et al. Influence of PEG coating on the biodistribution and tumor accumulation of pH-sensitive liposomes. Drug Delivery and Translational Research 2019; 9(1): 123–130. doi: 10.1007/s13346-018-0583-8
Kashkooli FM, Soltani M, Souri M. Controlled anti-cancer drug release through advanced nano-drug delivery systems: Static and dynamic targeting strategies. Journal of Controlled Release 2020; 327: 316–349. doi: 10.1016/j.jconrel.2020.08.012
Moghassemi S, Dadashzadeh A, Azevedo RB, et al. Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system. Journal of Controlled Release 2021; 339: 75–90. doi: 10.1016/j.jconrel.2021.09.024
Joshi S, Hussain MT, Roces CB, et al. Microfluidics based manufacture of liposomes simultaneously entrapping hydrophilic and lipophilic drugs. International Journal of Pharmaceutics 2016; 514(1): 160–168. doi: 10.1016/j.ijpharm.2016.09.027
Jain A, Jain SK. In vitro release kinetics model fitting of liposomes: An insight. Chemistry and Physics of Lipids 2016; 201: 28–40. doi: 10.1016/j.chemphyslip.2016.10.005
Manconi M, Marongiu F, Castangia I, et al. Polymer-associated liposomes for the oral delivery of grape pomace extract. Colloids and Surfaces B: Biointerfaces 2016; 146: 910–917. doi: 10.1016/j.colsurfb.2016.07.043
Li M, Du C, Guo N, et al. Composition design and medical application of liposomes. European Journal of Medicinal Chemistry 2019; 164: 640–653. doi: 10.1016/j.ejmech.2019.01.007
Wang J, Guo J, Wei Z. Strategies for liposome drug delivery systems to improve tumor treatment efficacy. AAPS PharmSciTech 2021; 23(1): 27. doi: 10.1208/s12249-021-02179-4
Rauti R, Musto M, Bosi S, et al. Properties and behavior of carbon nanomaterials when interfacing neuronal cells: How far have we come? Carbon 2019; 143: 430–446. doi: 10.1016/j.carbon.2018.11.026
Mohajeri M, Behnam B, Sahebkar A. Biomedical applications of carbon nanomaterials: Drug and gene delivery potentials. Journal of Cellular Physiology 2018; 234(1): 298–319. doi: 10.1002/jcp.26899
Wang SY, Hu HZ, Qing XC, et al. Recent advances of drug delivery nanocarriers in osteosarcoma treatment. Journal of Cancer 2020; 11(1): 69–82. doi: 10.7150/jca.36588
Bepete G, Coleman KS. Carbon nanotubes: Electronic structure and spectroscopy. In: Comprehensive Nanoscience and Nanotechnology, 2nd ed. Academic Press; 2019. pp. 205–218.
Ganji DD, Kachapi SHH. Semi nonlinear analysis in carbon nanotube. In: Application of Nonlinear Systems in Nanomechanics and Nanofluids, 1st ed. William Andrew Publishing; 2015. pp. 13–70.
Beg S, Rahman M, Jain A, et al. Emergence in the functionalized carbon nanotubes as smart nanocarriers for drug delivery applications. In: Grumezescu AM (editor). Fullerens, Graphenes and Nanotubes: A Pharmaceutical Approach. William Andrew; 2018. pp. 105–133.
Merum S, Babu VJ, Ramakrishna S. Functionalized carbon nanotubes in bio-world: Applications, limitations and future directions. Materials Science and Engineering: B 2017; 223: 43–63. doi: 10.1016/j.mseb.2017.06.002
Kushwaha SKS, Ghoshal S, Rai AK, Singh S. Carbon nanotubes as a novel drug delivery system for anticancer therapy: A review. Brazilian Journal of Pharmaceutical Sciences 2013; 49(4): 629–643. doi: 10.1590/S1984-82502013000400002
Liu D, Zhang Q, Wang J, et al. Hyaluronic acid-coated single-walled carbon nanotubes loaded with doxorubicin for the treatment of breast cancer. Pharmazie 2019; 74(2): 83–90. doi: 10.1691/ph.2019.8152
Uttekar PS, Lakade SH, Beldar VK, Harde MT. Facile synthesis of multi-walled carbon nanotube via folic acid grafted nanoparticle for precise delivery of doxorubicin. IET Nanobiotechnology 2019; 13(7): 688–696. doi: 10.1049/iet-nbt.2018.5421
Garcia CD, Crevillen AG, Escarpa A. Carbon-based Nanomaterials in Analytical Chemistry. Royal Society of Chemistry; 2018.
Bai RG, Husseini GA. Graphene-based drug delivery systems. In: Unnithan AR, Kurup Sasikala AR, Park CH, et al. (editors). Biomimetic Nanoengineered Materials for Advanced Drug Delivery. Elsevier; 2019; pp. 149–168.
Yang Y, Liu J, Sun X, et al. Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures. Nano Research 2016; 9: 139–148. doi: 10.1007/s12274-015-0898-4
Pattnaik S, Surendra Y, Rao JV, Swain K. 18—Carbon family nanomaterials for drug delivery applications. In: Mozafari M (editor). Nanoengineered Biomaterials for Advanced Drug Delivery. Elsevier; 2020; pp. 421–445.
Aliabadi M, Yunessnia lehi A, Shagholani H, Gerayeli A. Planar polymer-graphene oxide nanohybrid as a 5-fluorouacil carrier in pH-responsive controlled release. Journal of Drug Delivery Science and Technology 2018; 43: 103–106. doi: 10.1016/j.jddst.2017.09.020
Le Ouay B, Stellacci F. Antibacterial activity of silver nanoparticles: A surface science insight. Nano Today 2015; 10(3): 339–354. doi: 10.1016/j.nantod.2015.04.002
Praphakar RA, Jeyaraj M, Ahmed M, et al. Silver nanoparticle functionalized CS-g-(CA-MA-PZA) carrier for sustainable anti-tuberculosis drug delivery. International Journal of Biological Macromolecules 2018; 118: 1627–1638. doi: 10.1016/j.ijbiomac.2018.07.008
Jain S, Hirst DG, O’Sullivan JM. Gold nanoparticles as novel agents for cancer therapy. The British Journal of Radiology 2012; 85(1010): 101–113. doi: 10.1259/bjr/59448833
Chow EKH, Ho D. Cancer nanomedicine: From drug delivery to imaging. Science Translational Medicine 2013; 5(216): 216rv4. doi: 10.1126/scitranslmed.3005872
LiSunita Kumbhat NK. Carbon-based nanomaterials. In: Essentials in Nanoscience and Nanotechnology, 1st ed. Wiley; 2016. pp. 189–236.
Shah A, Aftab S, Nisar J, et al. Nanocarriers for targeted drug delivery. Journal of Drug Delivery Science and Technology 2021; 62: 102426. doi: 10.1016/j.jddst.2021.102426
Hirsjarvi S, Passirani C, Benoit JP. Passive and active tumour targeting with nanocarriers. Current Drug Discovery Technologies 2011; 8(3): 188–196. doi: 10.2174/157016311796798991
Tiloke C, Phulukdaree A, Anand K, et al. Moringa oleifera gold nanoparticles modulate oncogenes, tumor suppressor genes, and caspase-9 splice variants in A549 cells. Journal of Cellular Biochemistry 2016; 117(10): 2302–2314. doi: 10.1002/jcb.25528
Cui W, Li J, Zhang Y, et al. Effects of aggregation and the surface properties of gold nanoparticles on cytotoxicity and cell growth. Nanomedicine: Nanotechnology, Biology and Medicine 2012; 8(1): 46–53. doi: 10.1016/j.nano.2011.05.005
Gong N, Chen S, Jin S, et al. Effects of the physicochemical properties of gold nanostructures on cellular internalization. Regenerative Biomaterials 2015; 2(4): 273–280. doi: 10.1093/rb/rbv024
Albanese A, Tang PS, Chan WCW. The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annual Review of Biomedical Engineering 2012; 14: 1–16. doi: 10.1146/annurev-bioeng-071811-150124
Farooq MU, Novosad V, Rozhkova EA, et al. Retracted article: Gold nanoparticles-enabled efficient dual delivery of anticancer therapeutics to HeLa cells. Scientific Reports 2018; 8(1): 2907. doi: 10.1038/s41598-018-21331-y
Gurunathan S, Qasim M, Choi Y, et al. Antiviral potential of nanoparticles—Can nanoparticles fight against coronaviruses? Nanomaterials 2020; 10(9): 1645. doi: 10.3390/nano10091645
Yuan YG, Zhang S, Hwang JY, Kong IK. Silver nanoparticles potentiates cytotoxicity and apoptotic potential of camptothecin in human cervical cancer cells. Oxidative Medicine and Cellular Longevity 2018; 2018: 6121328. doi: 10.1155/2018/6121328
Li Y, Lin Z, Zhao M, et al. Reversal of H1N1 influenza virus-induced apoptosis by silver nanoparticles functionalized with amantadine. RSC Advances 2016; 6(92): 89679–89686. doi: 10.1039/C6RA18493F
Copyright (c) 2023 Nazish Jahan, Noor Ul Huda, Arooj Fatima, Huma Shamshad
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors contributing to this journal agree to publish their articles under the Creative Commons Attribution 4.0 International License, allowing third parties to share their work (copy, distribute, transmit) and to adapt it for any purpose, even commercially, under the condition that the authors are given credit. With this license, authors hold the copyright.
