Effects of flubendiamide and lead exposure on circulating thyroid hormone levels in buffalo (Bubalus bubalis) calves

Amita  Ranjan; Vinod Kumar  Dumka; Rahini  Parsoya; Rakesh  Ranjan

doi:10.59400/jts1794

Effects of flubendiamide and lead exposure on circulating thyroid hormone levels in buffalo (Bubalus bubalis) calves

Amita Ranjan Deptt of Veterinary Pharmacology and Toxicology, Guru Angad Dev veterinary and Animal Sciences University, Ludhiana 141004, India; Deptt of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Rajasthan University of Veterinary and Animal Sciences University, Bikaner 334001, India
Vinod Kumar Dumka Deptt of Veterinary Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Rajasthan University of Veterinary and Animal Sciences University, Bikaner 334001, India
Rahini Parsoya ICAR-National Research Centre on Camel, Bikaner 334001, India
Rakesh Ranjan ICAR-National Research Centre on Camel, Bikaner 334001, India

Article ID: 1794

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DOI: https://doi.org/10.59400/jts1794

Keywords: flubendiamide; lead; pesticide; thyroid-hormone; toxicity

Abstract

The current investigation aimed to find how exposure to lead and flubendiamide affected the amounts of thyroid hormone levels in buffalo calves’ blood. For ninety days, male buffalo calves were given lead acetate orally at a rate of 9.2 mg/kg bw/day and flubendiamide orally at a rate of 0.024 mg/kg bw/day, either in combination or separately. T3 and T4 levels in blood decreased in response to both flubendiamide and lead exposure alone. When lead and flubendiamide were administered together, the animals’ T3 and T4 levels declined less than when lead and flubendiamide were administered separately. TSH activity increased markedly in rats exposed to both lead and flubendiamide, but not consistently in animals treated with flubendiamide alone. Results of the present study indicated thyrotoxic potential of flubendiamide and lead in buffalo calves. However, further study is required to elucidate the mechanism of thyrotoxic potential of flubendiamide and to understand the interactive effects of these two toxicants on thyroid function in mammals.

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Published

2024-12-23

How to Cite

Ranjan, A., Dumka, V. K., Parsoya, R., & Ranjan, R. (2024). Effects of flubendiamide and lead exposure on circulating thyroid hormone levels in buffalo (Bubalus bubalis) calves. Journal of Toxicological Studies, 3(1), 1794. https://doi.org/10.59400/jts1794

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