Is acetylsalicylic acid use in cats contraindicated or limited indicated?

Said Cafer; Bengü Bilgiç; Mehmet Erman Or

doi:10.59400/jts.v2i2.1486

Said Cafer Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University-Cerrahpaşa, Istanbul 34315, Turkey
Bengü Bilgiç Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University-Cerrahpaşa, Istanbul 34315, Turkey
Mehmet Erman Or Department of Internal Medicine, Faculty of Veterinary Medicine, Istanbul University-Cerrahpaşa, Istanbul 34315, Turkey

Article ID: 1486

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DOI: https://doi.org/10.59400/jts.v2i2.1486

Keywords: aspirin; NSAID’s; ulcer; salicylate; thromboembolism; toxicity

Abstract

Acetylsalic acid, (Aspirin^®) is a nonsteroidal anti-inflammatory drug (NSAID) widely used in human and veterinary medicine, especially for its analgesic and antithrombotic effects, mainly in the prevention of cardiovascular complications and in the treatment of various diseases. Aspirin^® can not be metabolized in cats because they do not have the enzyme glucuronyl transferase. For this reason, it has a long half-life and a narrow dose range. High dose administration in cats may cause serious toxicity in the liver. Acetylsalicylic acid is known to cause gastric ulcers associated with decreased prostaglandin levels. For these reasons, it is considered toxic to cats. But it also has antipyretic, analgesic, anti-inflammatory and antithrombotic properties. It is indicated for use alone or in combination with other antithrombotic drugs in the treatment and prophylaxis of thrombus formation resulting from cardiovascular diseases. This review aims to examine the indicated and contraindicated areas of use of Aspirin^®, which is widely considered toxic in cats.

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