Vol. 1 No. 1 (2023)

  • Open Access

    Review Articles

    Article ID: 270

    Cordyceps at a glance: Miraculous metabolite and molecular insights

    by Loknath Deshmukh, Rupesh Thakur, Aanchal Sonkuwar, Sardul Singh Sandhu

    Metabolism Studies, Vol.1, No.1, 2023; 109 Views, 74 PDF Downloads

    As an entomopathogenic fungus with significant pharmacological and therapeutic implications, particularly for human health, Cordyceps sp. is a good alternative for ethnopharmacological use. A unique bio-metabolite termed Cordycepin (3′deoxyadenosine), which has extremely significant anti-cancer, anti-oxidant, and anti-inflammatory properties, is the main component of the extract made from this fungus. Due to their diverse biological functions, Cordyceps fungi have long drawn the interest of scientists; nonetheless, it has been difficult to successfully isolate active monomer molecules from them. Fungi produce significantly fewer substances in the lab than they do in the wild. In this review, I go through recent discoveries about the transcriptional and epigenetic control of BGCs as well as the ecological functions of fungal secondary metabolites in development, defense, and warfare. I also look at ways to find new fungal metabolites and the difficulties associated with gathering secondary metabolites derived from fungi. Metabolites serve a variety of purposes, including energy production, structural support, signaling and modulation of enzyme activity (often as an enzyme cofactor), defense, and interactions with other organisms (such as the production of pigments, odorants, and pheromones). Refocusing and reviving efforts to mine the fungal secondary metabolome has been one of the most interesting developments in the field of microbiology. Cordyceps sp., an entomopathogenic fungus, is a potential ethnopharmacological source due to its unique bio-metabolite, Cordycepin, which has anti-cancer, anti-oxidant, and anti-inflammatory properties. Its potential applications include immune system effects, DNA technology, metagenomics, kidney and cardiovascular systems, and cancer prevention in food and cosmetic industries.

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  • Open Access

    Review Articles

    Article ID: 1193

    Bio-Metabolomic odyssey: Deciphering the antimicrobial armamentarium of Endophytic Fungi in Anogeissus latifolia and related Sps. for therapeutic advancements

    by Vibhuti Sabhlok, Pavan Jain, Shama J. P. Khanam, Aanchal Sonkuwar, Sardul Singh Sandhu, Loknath Deshmukh

    Metabolism Studies, Vol.1, No.1, 2024; 45 Views, 26 PDF Downloads

    DOI: https://doi.org/10.59400/ms.v1i1.1193

    The review presents a comprehensive overview of the potential therapeutic advancements facilitated by microbial metabolites, particularly focusing on the symbiotic relationship between endophytic fungi and Anogeissus latifolia and related species. These fungi produce a diverse array of metabolites with pharmacological significance, including antibacterial, anticancer, antioxidant, and anti-diabetic properties. The review highlights the importance of endophytic fungi in natural drug discovery, emphasizing their role in enhancing plant resilience and producing therapeutically relevant compounds. Chemical analysis of A. latifolia reveals compounds like ellagic acid derivatives and flavonoids with medicinal potential, while pharmacological investigations showcase the plant’s efficacy in traditional applications and its promising antibacterial properties. Methodologies for identifying and characterizing bioactive compounds, such as metabolomics and high-performance thin chromatography, are outlined, supporting the hypothesis that undiscovered bio-metabolites from endophytic fungi hold high antibacterial potential, thus offering new avenues for drug discovery. In conclusion, the exploration of microbial metabolites, particularly those derived from endophytic fungi in A. latifolia, presents promising opportunities for developing novel, environmentally friendly, and effective therapies. This review underscores the significance of A. latifolia in herbal medicine and drug discovery, emphasizing the importance of preserving biodiversity and sustainable resource utilization.

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