Bio-Metabolomic odyssey: Deciphering the antimicrobial armamentarium of Endophytic Fungi in Anogeissus latifolia and related Sps. for therapeutic advancements
Abstract
The review presents a comprehensive overview of the potential therapeutic advancements facilitated by microbial metabolites, particularly focusing on the symbiotic relationship between endophytic fungi and Anogeissus latifolia and related species. These fungi produce a diverse array of metabolites with pharmacological significance, including antibacterial, anticancer, antioxidant, and anti-diabetic properties. The review highlights the importance of endophytic fungi in natural drug discovery, emphasizing their role in enhancing plant resilience and producing therapeutically relevant compounds. Chemical analysis of A. latifolia reveals compounds like ellagic acid derivatives and flavonoids with medicinal potential, while pharmacological investigations showcase the plant’s efficacy in traditional applications and its promising antibacterial properties. Methodologies for identifying and characterizing bioactive compounds, such as metabolomics and high-performance thin chromatography, are outlined, supporting the hypothesis that undiscovered bio-metabolites from endophytic fungi hold high antibacterial potential, thus offering new avenues for drug discovery. In conclusion, the exploration of microbial metabolites, particularly those derived from endophytic fungi in A. latifolia, presents promising opportunities for developing novel, environmentally friendly, and effective therapies. This review underscores the significance of A. latifolia in herbal medicine and drug discovery, emphasizing the importance of preserving biodiversity and sustainable resource utilization.
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