Bio-Metabolomic odyssey: Deciphering the antimicrobial armamentarium of Endophytic Fungi in Anogeissus latifolia and related Sps. for therapeutic advancements

Vibhuti  Sabhlok; Pavan Jain; Shama J. P.  Khanam; Aanchal  Sonkuwar; Sardul Singh  Sandhu; Loknath  Deshmukh

doi:10.59400/ms.v1i1.1193

Vibhuti Sabhlok School of Basic and Applied Science, Eklavya University, Damoh 470661, Madhya Pradesh, India
Pavan Jain School of Basic and Applied Science, Eklavya University, Damoh 470661, Madhya Pradesh, India
Shama J. P. Khanam School of Basic and Applied Science, Eklavya University, Damoh 470661, Madhya Pradesh, India
Aanchal Sonkuwar Bio-Design Innovation Centre, R.D. University, Jabalpur 482001, Madhya Pradesh, India
Sardul Singh Sandhu Bio-Design Innovation Centre, R.D. University, Jabalpur 482001, Madhya Pradesh, India
Loknath Deshmukh Bio-Design Innovation Centre, R.D. University, Jabalpur 482001, Madhya Pradesh, India; School of Life & Allied Sciences, ITM University, Raipur 493661, Chhattisgarh, India

Article ID: 1193

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DOI: https://doi.org/10.59400/ms.v1i1.1193

Keywords: bio-metabolites; pharmacological insights; medicinal plants; endophytic fungi; therapeutic applications; future prospects; bio-potentiality

Abstract

The review presents a comprehensive overview of the potential therapeutic advancements facilitated by microbial metabolites, particularly focusing on the symbiotic relationship between endophytic fungi and Anogeissus latifolia and related species. These fungi produce a diverse array of metabolites with pharmacological significance, including antibacterial, anticancer, antioxidant, and anti-diabetic properties. The review highlights the importance of endophytic fungi in natural drug discovery, emphasizing their role in enhancing plant resilience and producing therapeutically relevant compounds. Chemical analysis of A. latifolia reveals compounds like ellagic acid derivatives and flavonoids with medicinal potential, while pharmacological investigations showcase the plant’s efficacy in traditional applications and its promising antibacterial properties. Methodologies for identifying and characterizing bioactive compounds, such as metabolomics and high-performance thin chromatography, are outlined, supporting the hypothesis that undiscovered bio-metabolites from endophytic fungi hold high antibacterial potential, thus offering new avenues for drug discovery. In conclusion, the exploration of microbial metabolites, particularly those derived from endophytic fungi in A. latifolia, presents promising opportunities for developing novel, environmentally friendly, and effective therapies. This review underscores the significance of A. latifolia in herbal medicine and drug discovery, emphasizing the importance of preserving biodiversity and sustainable resource utilization.

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