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    Article ID: 270

    Cordyceps at a glance: Miraculous metabolite and molecular insights

    by Loknath Deshmukh, Rupesh Thakur, Aanchal Sonkuwar, Sardul Singh Sandhu

    Metabolism Studies, Vol.1, No.1, 2023; 90 Views, 62 PDF Downloads

    As an entomopathogenic fungus with significant pharmacological and therapeutic implications, particularly for human health, Cordyceps sp. is a good alternative for ethnopharmacological use. A unique bio-metabolite termed Cordycepin (3′deoxyadenosine), which has extremely significant anti-cancer, anti-oxidant, and anti-inflammatory properties, is the main component of the extract made from this fungus. Due to their diverse biological functions, Cordyceps fungi have long drawn the interest of scientists; nonetheless, it has been difficult to successfully isolate active monomer molecules from them. Fungi produce significantly fewer substances in the lab than they do in the wild. In this review, I go through recent discoveries about the transcriptional and epigenetic control of BGCs as well as the ecological functions of fungal secondary metabolites in development, defense, and warfare. I also look at ways to find new fungal metabolites and the difficulties associated with gathering secondary metabolites derived from fungi. Metabolites serve a variety of purposes, including energy production, structural support, signaling and modulation of enzyme activity (often as an enzyme cofactor), defense, and interactions with other organisms (such as the production of pigments, odorants, and pheromones). Refocusing and reviving efforts to mine the fungal secondary metabolome has been one of the most interesting developments in the field of microbiology. Cordyceps sp., an entomopathogenic fungus, is a potential ethnopharmacological source due to its unique bio-metabolite, Cordycepin, which has anti-cancer, anti-oxidant, and anti-inflammatory properties. Its potential applications include immune system effects, DNA technology, metagenomics, kidney and cardiovascular systems, and cancer prevention in food and cosmetic industries.

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