Metabolism Studies

Cordyceps at a glance: Miraculous metabolite and molecular insights

Loknath Deshmukh, Rupesh Thakur, Aanchal Sonkuwar, Sardul Singh Sandhu — Fri, 15 Dec 2023 00:00:00 +0000

As an entomopathogenic fungus with significant

pharmacological and therapeutic implications, particularly for human

health, Cordyceps sp. is a good alternative for ethnopharmacological use.

A unique bio-metabolite termed Cordycepin (3′deoxyadenosine), which

has extremely significant anti-cancer, anti-oxidant, and

anti-inflammatory properties, is the main component of the extract

made from this fungus. Due to their diverse biological functions,

Cordyceps fungi have long drawn the interest of scientists; nonetheless, it

has been difficult to successfully isolate active monomer molecules from

them. Fungi produce significantly fewer substances in the lab than they

do in the wild. In this review, I go through recent discoveries about the

transcriptional and epigenetic control of BGCs as well as the ecological

functions of fungal secondary metabolites in development, defense, and

warfare. I also look at ways to find new fungal metabolites and the

difficulties associated with gathering secondary metabolites derived

from fungi. Metabolites serve a variety of purposes, including energy

production, structural support, signaling and modulation of enzyme

activity (often as an enzyme cofactor), defense, and interactions with

other organisms (such as the production of pigments, odorants, and

pheromones). Refocusing and reviving efforts to mine the fungal

secondary metabolome has been one of the most interesting

developments in the field of microbiology. Cordyceps sp., an

entomopathogenic fungus, is a potential ethnopharmacological source

due to its unique bio-metabolite, Cordycepin, which has anti-cancer,

anti-oxidant, and anti-inflammatory properties. Its potential

applications include immune system effects, DNA technology,

metagenomics, kidney and cardiovascular systems, and cancer

prevention in food and cosmetic industries.

Bio-Metabolomic odyssey: Deciphering the antimicrobial armamentarium of Endophytic Fungi in Anogeissus latifolia and related Sps. for therapeutic advancements

Tue, 04 Jun 2024 08:21:27 +0000

The review presents a comprehensive overview of the potential therapeutic advancements facilitated by microbial metabolites, particularly focusing on the symbiotic relationship between endophytic fungi and Anogeissus latifolia and related species. These fungi produce a diverse array of metabolites with pharmacological significance, including antibacterial, anticancer, antioxidant, and anti-diabetic properties. The review highlights the importance of endophytic fungi in natural drug discovery, emphasizing their role in enhancing plant resilience and producing therapeutically relevant compounds. Chemical analysis of A. latifolia reveals compounds like ellagic acid derivatives and flavonoids with medicinal potential, while pharmacological investigations showcase the plant’s efficacy in traditional applications and its promising antibacterial properties. Methodologies for identifying and characterizing bioactive compounds, such as metabolomics and high-performance thin chromatography, are outlined, supporting the hypothesis that undiscovered bio-metabolites from endophytic fungi hold high antibacterial potential, thus offering new avenues for drug discovery. In conclusion, the exploration of microbial metabolites, particularly those derived from endophytic fungi in A. latifolia, presents promising opportunities for developing novel, environmentally friendly, and effective therapies. This review underscores the significance of A. latifolia in herbal medicine and drug discovery, emphasizing the importance of preserving biodiversity and sustainable resource utilization.

Electrolyzed hydrogen water and photobiomodulation therapy have several features in common

Michael R. Hamblin — Thu, 14 Sep 2023 15:42:12 +0000

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