SARS-CoV-2: Mapping its features that made it as a unique virus

Amro Abd Al Fattah Amara

doi:10.59400/ephr.v1i1.490

Amro Abd Al Fattah Amara Protein Research Department, Genetic Engineering and Biotechnology Research Institute, City of Scientific Research and Technological Applications, New Borg Al Arab 21934, Alexandria, Egypt

Ariticle ID: 490

107 Views, 40 PDF Downloads

DOI: https://doi.org/10.59400/ephr.v1i1.490

Keywords: epitopes; control strategies; immunopeptidome; vaccine; variant; SARS-CoV-2

Abstract

SARS-CoV-2 has attracted the attention of nearly the whole world during the last four years. It is a Corona virus that is responsible for the deaths of millions. It is responsible for economic corruption in many countries. As a response, excessive vaccination programs were installed everywhere. But many variants are elevated, and the virus proves its ability to escape from the immune system because of different mutations. The progress in different scientific domains—instrumentation, bioinformatics, and the like—makes fast vaccine development easier. As a response, new strategies were introduced, including new vaccine production and administration strategies, genomic surveillance, immunopeptidome, gene sequencing, and the like, to enable the vaccine to cover all the targeted populations at the correct time and to install an early alarm system against any elevated new variants. This review contains more information about some important stations in the history of vaccine development and the strategies invented by scientists to control different viruses and other microbes. Some important issues that might influence the type of vaccine used for SARS-CoV-2 are addressed. They include their symptoms, the virus evasion of the innate immune system, the response of adaptive immunity, and the like. Although the world still needs to better understand the SARS-CoV-2 behavior to win the war against it, previous historical successful vaccine productions, important examples, and stations during the human struggle against the viruses are described and discussed.

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